3-aminocarbonyl-1, 4-dihydropyridine-5-carboxylic acid derivative, production thereof and drug composition


NEW MATERIAL:A compound shown by formula I(R 1 is H, 1W5C alkyl, 2W5C alkenyl, 3W5C alkynyl, etc.,; R 2 is 1W10C alkyl; NO 2 is replaced at the ortho- or meta-position; etc.,). EXAMPLE: 2, 6-Dimethyl-3-siopropylaminocarbonyl-4-(o-nitrophenyl)-1,4-dihydro pyridine- 5-carboxylic acid n-heptyl ester. USE: A preventive and remedy for circulatory diseases having hypotensive, gelangiectatic, coronary vasodilating, cerebrovascular vasodilating action, vasodilating action on blood vessel of kidney, etc., mild development of action and durability. PREPARATION: An o-(or m-) nitrobenzylideneacetoacetic alkyl ester shown by formula II and an aminocrotonic acid amide shown by formula III are subjected to ring closure reaction in a solvent such as benzene, etc., at 50W130°C to give a compound shown by formula I. COPYRIGHT: (C)1987,JPO&Japio




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    JP-2006508890-AMarch 16, 2006ヴィッタル マリア サイエンティフィック リサーチ ファウンデーションカルシウムチャンネル遮断剤としての1,4−ジヒドロピリジンおよびピリジン化合物