Analogues de bombesine utilises dans le traitement du cancer

Bombesin analogs for treatment of cancer

Abstract

La présente invention concerne de nouveaux peptides, en l'occurrence des antagonistes de la bombésine et des peptides du type bombésine, qui sont utiles dans le traitement du cancer. L'invention concerne, en particulier, la conception et la synthèse de ces nouveaux peptides qui comprennent des α,α-acides aminés d'une manière spécifique au site. L'invention concerne, en outre, des procédés de génération desdits peptides, des compositions les renfermant et les applications pharmacologiques de ces peptides, notamment dans le traitement et la prévention du cancer.
The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the design and synthesis of the novel peptides incorporating α,α-amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (4)

    Publication numberPublication dateAssigneeTitle
    EP-0315367-A2May 10, 1989Imperial Chemical Industries PlcPolypeptide
    EP-0345990-A2December 13, 1989Zeneca LimitedPolypeptid-Verbindungen
    EP-0468497-A2January 29, 1992Merrell Pharmaceuticals Inc.Peptide mit Bombesin/GRP-antagonistischer Wirkung
    WO-0047221-A1August 17, 2000National Institute Of Immunology, Dabur Research Foundation, Cord, Janet, I.Antiangiogenic drugs

NO-Patent Citations (0)

    Title

Cited By (12)

    Publication numberPublication dateAssigneeTitle
    EP-1706154-A1October 04, 2006Bracco Imaging, S.P.A.Composes peptidiques de liberation de gastrine ameliores
    EP-1706154-A4November 26, 2008Bracco SpaVerbesserte gastrinfreisetzende peptidverbindungen
    US-7611692-B2November 03, 2009Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    US-7850947-B2December 14, 2010Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    US-7922998-B2April 12, 2011Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    US-8414864-B2April 09, 2013Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    US-8420050-B2April 16, 2013Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    US-8420053-B2April 16, 2013Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    US-8444954-B2May 21, 2013Bracco Imaging S.P.A.Gastrin releasing peptide compounds
    WO-2004056387-A1July 08, 2004Dabur Research FoundationAnalogues de peptides de synthese pour traiter le cancer
    WO-2009043522-A2April 09, 2009Mondobiotech Laboratories AgUtilisation d'un peptide en tant qu'agent thérapeutique
    WO-2009043522-A3August 06, 2009Mondobiotech Lab Ag, Dorian Bevec, Fabio Cavalli, Vera Cavalli, Gerald BacherUse of a peptide as a therapeutic agent